• Social Inequalities in Ageing
• Centre of Excellence in Research on Ageing and Care
• Vitality 90+ Study

2022- Chair in the Finnish Society for Growth and Ageing Research

2022- Board member in the Nordic Gerontological Federation

2022- Member of the Faculty Council, Tampere University, Faculty of Social Sciences

2020-2021 Board member in Gerontology Research Center

2015-2022 Board member in the Finnish Society for Growth and Ageing Research, A deputy member 2018-2022

2017-2020 Secretary and an accountant in the Nordic Gerontological Federation

2018-2020 Deputy member of the board in the GeroCenter Foundation 

2014-2016 Membership secretary in the Finnish Society for Growth and Ageing Research

Peer reviewed publications

Nosraty L, Nevalainen J, Raitanen J, Enroth L. 2024. Tree-based analysis of longevity predictors and their ten-year changes: a 35-Year mortality follow-up. BMC Geriatrics 24, 817. https://doi.org/10.1186/s12877-024-05404-4 

Enroth L, Halonen P, Tiainen K, Raitanen J, Jylhä M. 2023. Cohort profile: The Vitality 90+ Study. A cohort study on health and living conditions of the oldest old in Tampere, Finland. BMJ open, 13(2). http://dx.doi.org/10.1136/bmjopen-2022-068509 

Halonen P, Jämsen E, Enroth L, Jylhä M. 2023. Agreement between self-reported information and health register data on chronic diseases in the oldest old. Clinical Epidemiology 785-794. https://doi.org/10.2147/CLEP.S410971 

Vargese S, Jylhä M, Raitanen J, Enroth L, Halonen P, Aaltonen M. 2023. Dementia-related disability in the population aged 90 years and over: Differences over time and the role of comorbidity in the Vitality 90+ Study. BMC Geriatrics 23(1), 276. https://doi.org/10.1186/s12877-023-03980-5 

Halonen P, Enroth L, Tiainen K, Jylhä M 2022. Dementia and related comorbidities in the population aged 90 and over in the Vitality 90+ Study, Finland: patterns and trends from 2001 to 2018. Journal of Aging and Health. https://doi.org/10.1177/08982643221123451  

Enroth L, Jasilionis D, Németh L, Strand BH, Tanjung I, Sundberg L, Fors S, Jylhä M & Brønnum-Hansen H. Changes in socioeconomic differentials in old age life expectancy in four Nordic countries – The impact of educational expansion and education-specific mortality. European Journal of Ageing, 19, 161–173. https://doi.org/10.1007/s10433-022-00698-y  

Enroth L, Fors S 2021. Trends in the social class inequalities in disability and self-rated health: Repeated cross-sectional surveys from Finland and Sweden 2001-2018. International Journal of Public Health, 66:645513. https://doi.org/10.3389/ijph.2021.645513 

Kananen L, Enroth L, Raitanen J, Jylhävä J, Bürkle A, Moreno Villanueva M, Bernhardt J, Toussaint O, Grubeck Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S, Gonos E.S, Sikora E, Gradinaru D, Jansen E.H.J.M, Dollé M.E.T, Salmon M, Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom P.E, Talbot D.C.S, Libert C, Koskinen S, Bruunsgaard H, Hansen Å.M, Lund R, Hurme M, Jylhä M 2021. Self rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. Scientific Reports 11, 6139. https://doi.org/10.1038/s41598-021-85668-7 

Enroth L, Pulkki J 2021. Aistivaikeudet, arki ja toimintakyky 90 vuotta täyttäneillä. (Sensory difficulties, everyday life and functional ability among people aged 90+). Gerontologia, 35(2), 121-137. https://doi.org/10.23989/gerontologia.96102   

Enroth L, Raitanen J, Halonen P, Tiainen K, Jylhä M 2021. Trends of Physical Functioning, Morbidity, and Disability-Free Life Expectancy Among the Oldest Old: Six Repeated Cross-Sectional Surveys Between 2001 and 2018 in the Vitality 90+ Study. The Journals of Gerontology; Series A, 76(7), 1227-1233. https://doi.org/10.1093/gerona/glaa144 

Enroth L, Veenstra M, Aartsen M, Kjær AA, Juul Nilsson C & Fors S 2019. Are there educational disparities in health among the oldest old? Evidence from the Nordic countries. European Journal of Ageing, 16, 415-424. https://doi.org/10.1007/s10433-019-00517-x 

Hoogendijk EO, van der Noordt M, Onwuteaka-Philipsen BD, Deeg DJH, Huisman M, Enroth L & Jylhä M 2019. Sex differences in healthy life expectancy among nonagenarians: A multistate survival model using data from the Vitality 90+ study. Experimental Gerontology, 116, 80-85. https://doi.org/10.1016/j.exger.2018.12.015 

Halonen P, Raitanen J, Enroth L, Jämsen E & Jylhä M 2019. Chronic conditions and multimorbidity in population aged 90 years and over: associations with mortality and long-term care admission. Age and Ageing, 48(4), 564-570. https://doi.org/10.1093/ageing/afz019 

Nosraty L, Pulkki J, Raitanen J, Enroth L & Jylhä M 2019. Successful Aging as a Predictor of Long-Term Care Among Oldest Old: The Vitality 90+ Study. Journal of Applied Gerontology, 38(4), 553-571. https://doi.org/10.1177/0733464817716968 

Jylhä M, Enroth L, Halonen P (2019). Vanhoista vanhimpien terveys ja toimintakyky. Duodecim, 135 (11), 1085-1091.

Enroth L, Aaltonen M, Raitanen J, Nosraty L & Jylhä M 2018. Does use of long-term care differ between occupational classes among the oldest old? Vitality 90+ Study. European Journal of Ageing, 15(2), 143-153. https://link.springer.com/article/10.1007%2Fs10433-017-0445-0 

Jørgensen TSH, Fors S, Nilsson CJ, Enroth L, Aaltonen M, Sundberg L, Brønnum-Hansen H, Strand BH, Chang M ja Jylhä M. 2018. The ageing populations in the Nordic countries: mortality and longevity from 1990-2014. Scandinavian Journal of Public Health, 47(6), 611-617. https://doi.org/10.1093/eurpub/ckx187.608 

Kauppi M, Raitanen J, Stenholm S, Aaltonen M, Enroth L & Jylhä M 2018. Predictors of long-term care among nonagenarians: the Vitality 90 + Study with linked data of the care registers. Aging Clinical and Experimental Research, 30(8), 913-919. https://doi.org/10.1007/s40520-017-0869-6 

Halonen P, Enroth L, Jylhä M, Tiainen K. 2017. Pitkäaikaissairaudet ja monisairastavuus hyvin vanhoilla sekä niiden yhteys toimintakykyyn ja itse arvioituun terveyteen-Tervaskannot 90+ -tutkimus. (Chronic conditions and multimorbidity - associations with functioning and self-rated health among nonagenarians: The Vitality 90+ Study). Gerontologia, 31(4), 269-281. https://doi.org/10.23989/gerontologia.65943 

Enroth L, Raitanen J, Hervonen A, Lehtimäki T, Jylhävä J, Hurme M & Jylhä M 2016. Cardiometabolic and Inflammatory Biomarkers as Mediators between Educational Level and Functioning at the Age of 90 Years. The Journals of Gerontology; Series A, 71(3), 412–419. https://doi.org/10.1093/gerona/glv105   

Enroth L, Raitanen J, Hervonen A, Nosraty L & Jylhä M. 2015. Is Socioeconomic Status a Predictor of Mortality in Nonagenarians? The Vitality 90+ Study. Age and Ageing, 44, 123-129. https://doi.org/10.1093/ageing/afu092 

Nosraty L, Enroth L, Raitanen J, Hervonen A & Jylhä M. 2015. Do Successful Agers Live Longer? The Vitality 90+ Study. Journal of Aging and Health, 27(1), 35-53. https://doi.org/10.1177/0898264314535804 

Enroth L, Raitanen J, Hervonen A & Jylhä M. 2013. Do Socioeconomic Health Differences Persist in Nonagenarians? The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 68(5), 837-847. https://doi.org/10.1093/geronb/gbt067 

Jylhä M, Enroth L & Luukkaala T. 2013. Trends of functioning and health in nonagenarians − the Vitality 90+ Study. In Robine JM. Jagger C. & Crimmins E. Annual Review of Gerontology and Geriatrics, 33, ”Healthy Longevity”. Springer Publishing Company, 313-332. 

Helminen S, Sarkeala T, Enroth L, Hervonen A & Jylhä M. 2012. Vanhoista vanhimpien terveys ja elämäntilanne – tuloksia vuoden 2010 Tervaskannot 90+ -tutkimuksesta. Gerontologia, 26(3), 162–171. https://urn.fi/URN:NBN:fi:uta-201702131130   

THESES

Enroth L. 2017. Doctoral thesis: Social inequality in the health of the oldest old: Socioeconomic differences in health, functioning, mortality and long-term care use in the population aged 90+. University of Tampere, Tampere, Finland. Tampere University Press. (Acta Electronica Universitatis Tamperensis 1840). http://urn.fi/URN:ISBN:978-952-03-0599-4 

Enroth L. 2011. Master’s thesis: Sosioekonomiset erot vanhoista vanhimpien terveydessä. Tampereen yliopisto. http://urn.fi/urn:nbn:fi:uta-1-21599 

Amilon, A., Kjær, A.A., Ladenburg, J., Siren, A. (2022). Trust in the publicly financed care system and willingness to pay for long-term care: A discrete choice experiment in Denmark. Social Science and Medicine, 311: 115332. https://doi.org/10.1016/j.socscimed.2022.115332

Siren et al (2022) Negotiations of vulnerability in aging with vision impairment. Journal of Aging Studies, 61: 101036. https://doi.org/10.1016/j.jaging.2022.101036

Siren, A. (2022). Boformer og den aldrende befolkning. In T.A. Andersen & J. R. Skaksen (Eds.): Et aldrende Danmark. Gyldendal, Copenhagen. Pp. 77-86.

Amilon, A. & Siren, A. (2022). The link between vision impairment and depressive symptomatology in late life: does having a partner matter? European Journal of Ageing,19: 521–532

Siren, A. (2021). Beyond accessibility: Transport system as a societal structure supporting inclusion in late life. In K. Walsh, T. Scharf, S. Van Regenmortel & A. Wanka (eds.): Social Exclusion in Later Life: Interdisciplinary and Policy Perspectives. International Perspectives on Aging, Volume 28. Springer. DOI: 10.1007/978-3-030-51406-

Kjær, A.A. & Siren, A. (2021). Aging without children: The link between parental status and tangible support. Journal of Family Issues. doi: 10.1177/0192513X21993203

Filges, T., Siren, A., Fridberg, T. (2020). Voluntary work for the physical and mental health of older volunteers: A systematic review. Campbell Systematic Reviews. doi: 10.1002/cl2.1124.

Amilon, A. Ladenburg, J., Siren, A., Østergaard, S., (2020). Willingness to pay for long-term home care services: Evidence from a stated preferences analysis. The Journal of the Economics of Ageing. https://doi.org/10.1016/j.jeoa.2020.100238

Siren, A., Amilon, A., Larsen, G. K., Mehlsen, L. (2019). The promise of assistive technology in institutionalized care: economic efficiency, improved working conditions, and better quality of care? Disability and Rehabilitation: Assistive Technology. Publication before print. doi: 10.1080/17483107.2019.1659862

Kjær, A.A. & Siren, A. (2019). Formal and informal care: exploring trajectories of home care use among Danish older adults. Ageing and Society. Publication before print. doi:10.1017/S0144686X19000771.

Kjær, A. A., Siren, A., Seested, M. H., Fridberg, T. & Casier, F. (2019). Cohort profile: The Danish Longitudinal Study of Ageing (DLSA). International Journal of Epidemiology, 48: 1050-1050g. doi: 10.1093/ije/dyz026

Siren, A. & Casier, F. (2019). Socioeconomic and lifestyle determinants of giving practical support to adult children in the era of changing late life. Ageing and Society, 39(9): 1933-1950. doi:10.1017/S0144686X18000338 

Siren, A. & Knudsen, S. G. (2017) Older adults and the emerging digital service delivery. A mixed methods study on ICT use, skills and attitudes. Journal of Aging and Social Policy, 29(1): 35-50. doi: 10.1080/08959420.2016.1187036

Siren, A. & Haustein, S. (2016). How do baby boomers' mobility patterns change with retirement? Ageing and Society, 36: 988-1007. doi:10.1017/S0144686X15000100

Siren, A. & Haustein, S. (2016) Driving Cessation Anno 2010: Which older drivers give up their license and why? Evidence from Denmark. Journal of Applied Gerontology, 35(1): 18-38. doi: http://dx.doi.org/10.1177/0733464814521690.

Haustein, S. & Siren, A. (2015). Older people’s mobility: segments, factors, trends. Transport Reviews: A Transnational Transdisciplinary Journal, 35 (4): 466-487. doi: 10.1080/01441647.2015.1017867

Siren, A., Hjorthol, R., & Levin, L. (2015). Different types of out-of-home activities and well-being amongst urban residing old persons with mobility impediments. Journal of Transport & Health, 2: 14-21. doi: 10.1016/j.jth.2014.11.004

Siren, A. & Haustein, S. (2015) Driving licences and medical screening in old age. Review of literature and the European licensing policies. Journal of Transport & Health, 2: 68-78. doi:10.1016/j.jth.2014.09.003

Siren, A. & Haustein, S. (2015). What are the impacts of giving up the driver license? Ageing and Society, 35(9): 1821 – 1838. DOI: 10.1017/S0144686X14000610

Siren, A. & Sørensen, C. H. (2015). Immense changes in traffic—considerable stability in discourses. Road speed in Danish parliamentary documents 1900-2010. Transport Policy, 40: 1-7. doi: 10.1016/j.tranpol.2015.02.005

Meng, A. & Siren, A. (2015). Older drivers’ reasons for reducing the overall amount of their driving and for avoiding selected driving situations. Journal of Applied Gerontology, 34(3): NP62–NP82. doi: 10.1177/0733464812463433

Haustein, S. & Siren, A. (2014). Seniors' unmet mobility needs - how important is a driving licence? Journal of Transport Geography, 41:45-51.

Figueroa, M., Nielsen T.S., & Siren, A. (2014). Comparing Urban Form Correlations of the Travel Patterns of Older and Younger Adults. Transport Policy, 35, 10-20.

Siren, A. & Haustein, S. (2013). Baby boomers' mobility patterns and preferences: What are the implications for future transport demand? Transport Policy, 29: 136-144.

Siren, A. & Meng, A. (2013). Older drivers' self-assessed driving skills, driving-related stress and self-regulation in traffic. Transportation Research Part F: Traffic Psychology and Behaviour, 17: 88-97.

Meng, A., Siren, A. & Teasdale, T. (2013). Older drivers with cognitive impairment: perceived changes in driving skills, driving-related discomfort and self-regulation of driving. European Geriatric Medicine, 3: 154-160.

Meng, A. & Siren, A. (2012). Cognitive problems, self-rated changes in driving skills, driving-related discomfort and self-regulation of driving in old drivers. Accident Analysis and Prevention, 49: 322-329.

Siren, A. & Meng, A. (2012). Cognitive screening of older drivers does not produce safety benefits. Accident Analysis and Prevention, 45: 634-638.

Siren, A. & Kjær, M. R. (2011). How is the older road users’ perception of risk constructed? Transportation Research Part F: Traffic Psychology and Behaviour, 14(3): 222-228.

Hjorthol, R., Levin, L. & Siren, A. (2010). Mobility in different generations of older persons. The development of daily travel in different cohorts in Denmark, Norway and Sweden. Journal of Transport Geography, 18: 624-633.

Siren, A. & Hakamies-Blomqvist, L. (2009). Mobility and well-being in old age. Topics in Geriatric Rehabilitation, 25(1): 3-11.

Siren, A. & Hakamies-Blomqvist, L. (2006). Does gendered driving create gendered mobility? Community-related mobility of Finnish women and men aged 65+. Transportation Research Part F: Traffic Psychology and Behaviour, 9(5): 374-382.

Siren, A. & Hakamies-Blomqvist, L. (2005). Sense and Sensibility. A Narrative Study of Older Women’s Car Driving. Transportation Research Part F: Traffic Psychology and Behaviour, 8(3): 213-228.

Siren, A., & Hakamies-Blomqvist, L. (2004). Car as the grand equaliser? Demographic factors and mobility in Finnish men and women aged 65+. Transportation Research Part F: Traffic Psychology and Behaviour, 7(2): 107-118.

Siren, A., Hakamies-Blomqvist, L., & Lindeman, M. (2004). Driving cessation and health in older women. Journal of Applied Gerontology, 23(1): 58-69.

Hakamies-Blomqvist, L. & Siren, A. (2003). Deconstructing a Gender Difference: Driving Cessation and Personal Driving History of Older Women. Journal of Safety Research, 34(4):383-388.

• Ageing and social wellbeing (SoWell)
• Vitality 90+
• The Centre of Excellence in Research on Ageing and Care (CoE AgeCare)

Recent publications:

Abzhandadze T, Hoang MT, Raaschou P, Norgren J, Mo M, Molnar C, Xu H, Kananen
L, Åkerman M, Religa D, Eriksdotter M, Garcia-Ptacek S. Temporal trends in sex
differences in dementia care-results from the Swedish registry for
cognitive/dementia disorders, SveDem. Sci Rep. 2025 May 29;15(1):18890. doi:
10.1038/s41598-025-03055-y.

Tirkkonen A, Mak JKL, Eriksson JG, Halonen P, Jylhävä J, Hägg S, Enroth L,
Raitanen J, Hovatta I, Jääskeläinen T, Koskinen S, Haapanen MJ, von Bonsdorff
MB, Kananen L. Predicting cardiovascular morbidity and mortality with SCORE2
(OP) and Framingham risk estimates in combination with indicators of biological
ageing. Age Ageing. 2025 Mar 28;54(4):afaf075. doi: 10.1093/ageing/afaf075.

Rajić S, Delerue T, Ronkainen J, Zhang R, Ciantar J, Kostiniuk D, Mishra PP,
Lyytikäinen LP, Mononen N, Kananen L, Peters A, Winkelmann J, Kleber ME,
Lorkowski S, Kähönen M, Lehtimäki T, Raitakari O, Waldenberger M, Gieger C, März
W, Harville EW, Sebert S, Marttila S, Raitoharju E. Regulation of nc886
(vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases.
Clin Epigenetics. 2025 Apr 29;17(1):68. doi: 10.1186/s13148-025-01871-7.

Marttila S, Rajić S, Ciantar J, Mak JKL, Junttila IS, Kummola L, Hägg S,
Raitoharju E, Kananen L. Biological aging of different blood cell types.
Geroscience. 2025 Feb;47(1):1075-1092. doi: 10.1007/s11357-024-01287-w. Epub
2024 Jul 26.

Haapanen MJ, Kananen L, Mikkola TM, Jylhävä J, Wasenius NS, Eriksson JG, von
Bonsdorff MB. Frailty in Midlife as a Predictor of Changes in Body Composition
from Midlife into Old Age: A Longitudinal Birth Cohort Study. Gerontology.
2024;70(8):831-841. doi: 10.1159/000539204. Epub 2024 May 8.

Mak JKL, Skovgaard AC, Nygaard M, Kananen L, Reynolds CA, Wang Y, Kuja-
Halkola R, Karlsson IK, Pedersen NL, Hägg S, Soerensen M, Jylhävä J. Epigenome-
wide analysis of frailty: Results from two European twin cohorts. Aging Cell.
2024 Jun;23(6):e14135. doi: 10.1111/acel.14135. Epub 2024 Feb 27.

Kananen L, Molnár C, Ansker F, Kozlowska DJ, Hägg S, Jylhävä J, Religa D,
Raaschou P. Anticoagulant treatment and COVID-19 mortality among older adults
living in nursing homes in Sweden. Health Sci Rep. 2023 Nov 14;6(11):e1692. doi:
10.1002/hsr2.1692.

Mak JKL, Kananen L, Qin C, Kuja-Halkola R, Tang B, Lin J, Wang Y,
Jääskeläinen T, Koskinen S, Lu Y, Magnusson PKE, Hägg S, Jylhävä J. Unraveling
the metabolic underpinnings of frailty using multicohort observational and
Mendelian randomization analyses. Aging Cell. 2023 Aug;22(8):e13868. doi:
10.1111/acel.13868. Epub 2023 May 15.

Kananen L, Hong X, Annetorp M, Mak JKL, Jylhävä J, Eriksdotter M, Hägg S,
Religa D. Health progression for Covid-19 survivors hospitalized in geriatric
clinics in Sweden. PLoS One. 2023 Mar 22;18(3):e0283344. doi:
10.1371/journal.pone.0283344.

Kananen L. DNA methylation states in supercentenarians. Lancet Healthy
Longev. 2023 Feb;4(2):e57. doi: 10.1016/S2666-7568(23)00006-5.

Mak JKL, Eriksdotter M, Annetorp M, Kuja-Halkola R, Kananen L, Boström AM,
Kivipelto M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG,
Åkesson E, Sühl Öberg C, Olsson M, Cederholm T, Hägg S, Religa D, Jylhävä J. Two
Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients
in the Stockholm GeroCovid Study. Gerontology. 2023;69(4):396-405. doi:
10.1159/000527206. Epub 2022 Nov 30.

Marttila S, Tamminen H, Rajić S, Mishra PP, Lehtimäki T, Raitakari O,
Kähönen M, Kananen L, Jylhävä J, Hägg S, Delerue T, Peters A, Waldenberger M,
Kleber ME, März W, Luoto R, Raitanen J, Sillanpää E, Laakkonen EK, Heikkinen A,
Ollikainen M, Raitoharju E. Methylation status of <i>VTRNA2-1</i>/<i>nc886</i>
is stable across populations, monozygotic twin pairs and in majority of tissues.
Epigenomics. 2022 Sep;14(18):1105-1124. doi: 10.2217/epi-2022-0228. Epub 2022
Oct 5.

Kananen L, Hurme M, Bürkle A, Moreno-Villanueva M, Bernhardt J, Debacq-
Chainiaux F, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza F, Collino S,
Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M, Stuetz W,
Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom E, Talbot
D, Libert C, Raitanen J, Koskinen S, Härkänen T, Stenholm S, Ala-Korpela M,
Lehtimäki T, Raitakari OT, Ukkola O, Kähönen M, Jylhä M, Jylhävä J. Circulating
cell-free DNA in health and disease - the relationship to health behaviours,
ageing phenotypes and metabolomics. Geroscience. 2023 Feb;45(1):85-103. doi:
10.1007/s11357-022-00590-8. Epub 2022 Jul 21.

Mak JKL, Hägg S, Eriksdotter M, Annetorp M, Kuja-Halkola R, Kananen L,
Boström AM, Kivipelto M, Metzner C, Bäck Jerlardtz V, Engström M, Johnson P,
Lundberg LG, Åkesson E, Sühl Öberg C, Olsson M, Cederholm T, Jylhävä J, Religa
D. Development of an Electronic Frailty Index for Hospitalized Older Adults in
Sweden. J Gerontol A Biol Sci Med Sci. 2022 Nov 21;77(11):2311-2319. doi:
10.1093/gerona/glac069.

Kananen L, Eriksdotter M, Boström AM, Kivipelto M, Annetorp M, Metzner C,
Bäck Jerlardtz V, Engström M, Johnson P, Lundberg LG, Åkesson E, Sühl Öberg C,
Hägg S, Religa D, Jylhävä J, Cederholm T. Body mass index and Mini Nutritional
Assessment-Short Form as predictors of in-geriatric hospital mortality in older
adults with COVID-19. Clin Nutr. 2022 Dec;41(12):2973-2979. doi:
10.1016/j.clnu.2021.07.025. Epub 2021 Jul 29.

Kananen L, Marttila S. Ageing-associated changes in DNA methylation in X and
Y chromosomes. Epigenetics Chromatin. 2021 Jul 2;14(1):33. doi:
10.1186/s13072-021-00407-6.

Ämmälä AJ, Suvisaari J, Kananen L, Lönnqvist J, Ripatti S, Pirkola S, Paunio
T, Hovatta I. Childhood adversities are associated with shorter leukocyte
telomere length at adult age in a population-based study.
Psychoneuroendocrinology. 2021 Aug;130:105276. doi:
10.1016/j.psyneuen.2021.105276. Epub 2021 May 21.

Kananen L, Enroth L, Raitanen J, Jylhävä J, Bürkle A, Moreno-Villanueva M,
Bernhardt J, Toussaint O, Grubeck-Loebenstein B, Malavolta M, Basso A, Piacenza
F, Collino S, Gonos ES, Sikora E, Gradinaru D, Jansen EHJM, Dollé MET, Salmon M,
Stuetz W, Weber D, Grune T, Breusing N, Simm A, Capri M, Franceschi C, Slagboom
PE, Talbot DCS, Libert C, Koskinen S, Bruunsgaard H, Hansen ÅM, Lund R, Hurme M,
Jylhä M. Self-rated health in individuals with and without disease is associated
with multiple biomarkers representing multiple biological domains. Sci Rep. 2021
Mar 17;11(1):6139. doi: 10.1038/s41598-021-85668-7.

Kananen L, Hurme M, Jylhä M, Härkänen T, Koskinen S, Stenholm S, Kähönen M,
Lehtimäki T, Ukkola O, Jylhävä J. Circulating cell-free DNA level predicts all-
cause mortality independent of other predictors in the Health 2000 survey. Sci
Rep. 2020 Aug 14;10(1):13809. doi: 10.1038/s41598-020-70526-9. 

Marttila S, Viiri LE, Mishra PP, Kühnel B, Matias-Garcia PR, Lyytikäinen LP, Ceder T, Mononen N, Rathmann W, Winkelmann J, Peters A, Kähönen M, Hutri-Kähönen N, Juonala M, Aalto-Setälä K, Raitakari O, Lehtimäki T, Waldenberger M, Raitoharju E. (2021) Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs. Clin Epigenetics. 13(1):143.

Kananen L, Marttila S. (2021) Ageing-associated changes in DNA methylation in X and Y chromosomes. Epigenetics Chromatin. 14(1):33. 

Marttila S, Rovio S, Mishra PP, Seppälä I, Lyytikäinen L-P, Juonala M, Waldenberger M, Oksala N, Ala Korpela M, Harville E, Hutri Kähönen N, Kähönen M, Raitakari O, Lehtimäki T, Raitoharju E. (2021) Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health. Sci Rep. 11(1):9203.

Marttila S, Chatsirisupachai K, Palmer D, de Magalhães JP. Ageing-associated changes in the expression of lncRNAs in human tissues reflect a transcriptional modulation in ageing pathways. Mech Ageing Dev. 2020 Jan;185:111177.

Kananen L, Marttila S. (2019) Vanhenemisen biologiset mekanismit ja miten niihin voi vaikuttaa. Duodecim 135(11):1098-106. 

Kananen L, Marttila S, Nevalainen T, Kummola L, Junttila I, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M, Jylhävä J. (2016) The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies. Age (Dordr) 38(3):65.

Kananen L, Marttila S, Nevalainen T, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Lehtimäki T, Hurme M. (2016) Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study. BMC Genomics 17:103.

Marttila S, Kananen L, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Hurme M. (2015) Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny. Oncotarget. 6(31):30557-67.

Marttila S, Kananen L, Häyrynen S, Jylhävä J, Nevalainen T, Hervonen A, Jylhä M, Nykter M, Hurme M. (2015) Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression. BMC Genomics, 16:179.

Marttila S, Nevalainen T, Kananen L, Jylhävä J, Jylhä M, Hervonen A, Ilonen J, Hurme M. (2015) Number of sons contributes to ageing-associated inflammation. Sci Rep, 5:8631.

Marttila S, Jylhävä J, Nevalainen T, Nykter M, Jylhä M, Hervonen A, Tserel L, Peterson P, Hurme M. (2013) Transcriptional analysis reveals gender-specific changes in the aging of the human immune system. PLoS One 8:e66229.

Marttila S, Jylhävä J, Eklund C, Hervonen A, Jylhä M, Hurme M. (2011) Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells. Immun Ageing 8:9.

Marttila S, Jylhävä J, Pesu M, Hämäläinen S, Jylhä M, Hervonen A, Hurme M. (2011) IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence. Exp Gerontol 46:1000-1002.

• Vitality 90+
• COCTEL
• Vanheneminen ja sosiaalinen hyvinvointi (SoWell)
• Social Inequalities in Ageing (SIA)

AXA Research Fund´Scientific Board, member 2021-

Human Rights Delegation, member 2020- 

21 (perhaps) most important publications

1. Kananen, L, Enroth, L, Raitanen, J, Jylhava, J, Buerkle, A, Moreno-Villanueva, M, Bernhardt, J, Toussaint, O, Grubeck-Loebenstein, B, Malavolta, M, Basso, A, Piacenza, F, Collino, S, Gonos, E, S, Sikora, E, Gradinaru, D, Jansen, E. H. J. M, Dolle, M. E. T, Salmon, M, Stuetz, W, Weber, D, Grune, T, Breusing, N, Simm, A, Capri, M, Franceschi, C, Slagboom, P. E, Talbot, D. C. S, Libert, C, Koskinen, S, Bruunsgaard, H, Hansen, AM, Lund, R, Hurme, M, Jylhä, M. Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains. Scientific Reports 11, 6139, 2021. DOI: /10.1038/s41598-021-85668-7.

2. Enroth L, Raitanen J, Halonen P, Tiainen K, Jylhä M. Trends of Physical Functioning, Morbidity and Disability-free Life Expectancy among the Oldest Old: Six Repeated Cross-sectional Surveys between 2001 and 2018 in the Vitality 90+ Study. J Gerontol A Biol Sci Med Sci: 76(7): 1227-33, 2021 glaa144, 2020. DOI:10.1093/gerona/glaa144.

3. Lisko, I, Törmäkangas, T, Jylhä, M. Structure of self-rated health among the oldest old: Analyses in the total population and those living with dementia. SSM Popul Health. 2020 Mar 18; 11:100567. DOI: 10.1016/j.ssmph.2020.100567. PMID: 32258355; PMCID: PMC7110410.

4. Raitanen J, Stenholm S, Tiainen K, Jylhä M, Nevalainen J. Longitudinal change in physical functioning and dropout due to death among the oldest old: a comparison of three methods of analysis. European Journal of Ageing 17 (2): 207-216, 2020. DOI: 10.1007/s10433-019-00533-x.

5. Jylhä M. New ages of life – emergence of the oldest-old. Encyclopedia of Biomedical Gerontology: 479- 488, 2020. Ed. S. Rattan. Elsevier 2020. DOI: 10.1016/B978-0-12-801238-3.11395-9.

6. Halonen P, Raitanen J, Jämsen E, Enroth L, Jylhä M: Chronic conditions and multimorbidity in population aged 90 years and over: associations with mortality and long-term care. Age & Ageing 48 (4): 564-570, 2019. DOI: 10.1093/ageing/afz019.

7. Aaltonen M, Forma L, Pulkki J, Raitanen J, Rissanen P, Jylhä M. The joint impact of age at death and dementia on long-term care use in the last years of life - changes from 1996 to 2013 in Finland. Gerontology and Geriatric Medicine 5, 2019. DOI: 10.1177/2333721419870629.

8. Hoogendijk, EO, van der Noordt M, Onwuteaka-Philipsen BD, Deeg DJ.H, Huisman M, Enroth L, Jylhä M. Sex differences in healthy life expectancy among nonagenarians: A multistate survival model using data from Vitality 90+ study. Experimental Gerontology 116: 80-85, 2019. DOI: 10.1016/j.exger.2018.12.015. Epub 2018 Dec 24. PMID: 30590122.

9. Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E; Jylhä M; Wilson J.F. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nat Commun. 8(1):910, 2017 Oct. DOI: 10.1038/s41467-017-00934-5. PMID: 29030599 Free PMC Article.

10. Nosraty L, Jylhä M, Raittila T, Lumme-Sandt K. Perceptions by the oldest old of successful aging, Vitality 90+ Study. J Aging Stud. 32:50-8, 2015 Jan. DOI: 10.1016/j.jaging.2015.01.002. (Epub 2015 Jan 23). PubMed PMID: 25661856.

11. Enroth L, Raitanen J, Hervonen A, Nostraty L, Jylha M. Is socioeconomic status a predictor of mortality in nonagenarians? The Vitality 90+ study. Age and Ageing 44(1):123-9, 2014. DOI: 10.1093/ageing/afu092.

12. Galenkamp H, Deeg DJH, Huisman M, Hervonen A, Braam AW, Jylhä M. Is self-rated health still sensitive for changes in disease and functioning among nonagenarians? J Gerontol Psych Sci Soc Sci 68(5):848-858. 2013. DOI: 10.1093/geronh/gbt067. 

13. Tiainen K, Luukkaala T, Hervonen A, Jylhä M. Predictors of mortality in men and women aged 90 years and older: nine-year follow-up. Age & Ageing 42:468-475, 2013. DOI: 10.1093/ageing/aft030t.

14. Jylhä M. What is self-rated health and why does it predict mortality? Towards a unified conceptual model. Soc Sci Med 69(3):307-316, 2009 (Epub 10 June 2009).

15. Jylhä M, Volpato S, Guralnik JM: Self-rated health showed a graded association with frequently used biomarkers in a large population sample. J Clin Epidemiol 59 (5): 465-471, 2006. 

16. Jylha M. Old age and loneliness: cross-sectional and longitudinal analyses in the Tampere Longitudinal Study on Aging. Can J Aging. 23(2):157-68, 2004. 

17. Jylhä M, Guralnik JM, Balfour J, Fried LF: Walking difficulty, walking speed, and age as determinants of self-rated health, the Women´s Health and Aging Study. J Gerontol A_Biol 56A (10):M609-M617, 2001.

18. Jylhä M, Guralnik JM, Ferrucci L; Jokela J, Heikkinen E.: Is self-rated health comparable across genders and cultures? J Gerontol: Soc Sci 53B (3): S144 - S152, 1998.

19. Jylhä M: Self rated health revisited: exploring survey interview episodes with elderly respondents. Soc Sci Med 39(7):983-990, 1994.

20. Jylhä M. Vanheneminen, toiminta ja vuorovaikutus. Kirjassa: Vanheneminen ja elämänkulku, s. 106-134. Toim. P Pohjolainen, M Jylhä. Weilin & Göös, Mänttä, 1990. (Ageing, activity and interaction)

21. Jylhä M, Jokela J: Individual experiences as cultural - a cross cultural study on loneliness among the elderly. Ageing and Society 10:295-315, 1990.

• Tervaskannot 90+
• Vanheneminen ja sosiaalinen hyvinvointi (SoWell)

Tuominen, K., Lumme-Sandt, K., & Siren, A. (2025). Tervaskannot 90+ -tutkimuksen uudet elämäntarinahaastattelut valottavat hyvin iäkkäiden ihmisten tavallista elämää. Gerontologia, 39(1), 69–74. https://doi.org/10.23989/gerontologia.154888

Tuominen, Katariina (2023). Making Space for Social Relationships: Understanding ageing in social spaces. [Väitöskirja, Tampereen yliopisto]. Trepo Tampereen yliopiston julkaisuarkisto. https://urn.fi/URN:ISBN:978-952-03-3193-1 

Tuominen, K., Pirhonen, J., Lumme-Sandt, K., Ahosola, P. & Pietilä, I. (2023). No place to go? Older people reconsidering the meaning of social spaces in the context of the COVID-19 pandemic. Journal of Aging Studies, 67, Article 101167. https://doi.org/10.1016/j.jaging.2023.101167 

Tuominen, K., Pietilä, I., Jylhä, M. & Pirhonen, J. (2022). A home, an institution and a community? – Frames of social relationships and interaction in assisted living. International Journal of Ageing and Later Life, 16(1), 49–73. https://doi.org/10.3384/ijal.1652-8670.3540 

Tuominen, K. & Pirhonen J. (2019). “Who would take a 90-year-old?” Community-dwelling nonagenarians’ perceptions of social relationships. International Journal of Ageing and Later Life, 2019 13(1): 111-137.https://doi.org/10.3384/ijal.1652-8670.18387

Ahosola, P., Tuominen, K., Tiainen, K., Jylhä, M., & Jolanki, O. (2021). Mikä muuttui vai muuttuiko mikään? Yli 65-vuotiaiden arki korona-aikana. Gerontologia, 35(4), 342–355. https://doi.org/10.23989/gerontologia.103376   

Pirhonen, J., Seppänen, M., Pietilä, I., Tuominen, K., & Jylhä, M. (2021). Vanhuus ja sosiaalinen kuolema : Sosiaalisen kuoleman käsite vanhojen ihmisten haastattelupuheessa. Yhteiskuntapolitiikka, 86(1), 5-15. Retrieved from http://urn.fi/URN:NBN:fi-fe202102164942 

Pirhonen, J., Lolich, L., Tuominen, K., Jolanki, O., & Timonen, V. (2020). “These devices have not been made for older people's needs” – older adults' perceptions of digital technologies in Finland and Ireland. Technology in Society, 62, 101287. doi:https://doi.org/10.1016/j.techsoc.2020.101287   

Pirhonen, J., Jolanki, O., Tuominen, K. & Jylhä, M. (2019). Hyvinvointi vanhuudessa – valmistautumista, sopeutumista, luopumista ja hyväksymistä. Gerontologia, 33(3), 105-120. https://doi.org/10.23989/gerontologia.79424